blunted affect, alogia, anhedonia, asociality and avolition b) for each construct, symptoms due to identifiable factors, such as medication effects, psychotic symptoms or depression, should be distinguished from those regarded as primary c) the five constructs cluster in two factors, one including blunted affect and alogia and the other consisting of anhedonia, avolition and asociality. A consensus has recently been reached on the following aspects: a) five constructs should be considered as negative symptoms, i.e. Improvements in definition, characterization, assessment instruments and experimental models are needed in order to foster research aimed at developing effective interventions. ![]() They play a key role in the functional outcome of the disorder, and their management represents a significant unmet need. Negative symptoms have long been conceptualized as a core aspect of schizophrenia.
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